Essential Fatty Acids
Natures Pharmacopia
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Low fat has become the standard for
selecting food for a healthy diet. But
the general public is often confused
or misinformed about the effects -
positive and negative - of fats
and oils (collectively referred to
as lipids).
Despite sometimes conflicting data, the
evidence is mounting showing a direct
relationship between the typical high-fat
Standard American Diet (the SAD diet)
and the major degenerative diseases
of our time such as cancer and
heart disease.
There is now direct evidence that
excessive dietary fat may well function
as a carcinogen.1 However, fats (lipids)
are needed in our diet. They serve as
the most efficient source of calories
(9 per gram) and are essential to many
body functions, particularly the
production of hormones.
The real question is how
much fat (lipids)
and what kind of fat
do we need?
Dietary studies suggest that the most
likely protective benefit of a low fat diet
does not begin to appear until the fat
content of the diet dips below 25% of
total calories.2
Other studies indicate that it is not just
the amount of fat, but the type of fat that
we consume that is linked to cancer and
heart disease.
Fats are classified as saturated,
mono-unsaturated and polyunsaturated.
The human body cannot
function properly without
two polyunsaturated
fats: Linoleic (Omega 6)
and Alpha-Linolenic
Acid (Omega 3).
Collectively these are called Essential
Fatty Acids (EFAs) because they are
essential to normal cell structure and
body function.
An essential nutrient is one that must
come from the diet because the body
cannot manufacture it. ( Nutrients like
cholesterol are nonessential because the
body can make them from other nutrients.)
Both Linoleic (Omega 6) and Alpha-
Linolenic Acid (Omega 3) function as
components of nerve cells, cell
membranes and hormonelike substances
known as prostaglandins.
But each of these EFAs have some basic
differences which, in part, explains why
we need to consume both in our daily
diet. Although both are 18 carbon length
fatty acids, Alpha-Linolenic Acid has
three unsaturated bonds, while Linoleic
Acid only has two.
The different location of the first
unsaturated bond gives them the more
common names by which they are
frequently called: Alpha-Linolenic Acid's
first unsaturated bond occurs at the third
carbon (see Figure 1). It is known as an |
Alpha Linolenic Acid (Omega 3)
CH3CH2CH=CHCH2CH=CHCH2CH=CH(CH2)7COOH
Gamma Linolenic Acid (GLA)
CH3(CH2)4CH=CHCH2CH=CHCH2CH=CH(CH2)4COOH
Linoleic Acid (Omega 6)
CH3(CH2)4CH=CHCH2CH=CH(CH2)7COOH
Figure 1 |
Omega 3 oil. Linoleic Acid's first double
bond is at the sixth carbon. Thus, it is
referred to as an Omega 6 oil (see
Figure 1).
Due to these distinct differences, Linoleic
Acid and Alpha-Linolenic Acid form
entirely different prostaglandins. A deficiency
in either Essential Fatty Acid is
associated with decreased synthesis of
anti-inflammatory prostaglandins.
Many of the beneficial effects of chosing
a diet rich in plant foods are the result
of the low levels of saturated fat and
the relatively higher levels of essential
fatty acids.
Now there is increasing
evidence that the ratio
of Omega 3 to Omega
6 in the diet can play a
crucial role in the development
of many degenerative
diseases.
Dr. Rashda Karmali of the Memorial
Sloan-Kettering Cancer Center in New
York is one of the leaders in the study of
the relationship between the essential
fatty acids and cancer. At a NATO
Conference, she stated that she has found
that the best ratio of Omega 3 to Omega
6 for preventing cancer is a one to
one ratio.3
Most diets have become unbalanced due
to the extensive processing of our food
supply. Many food processors go to
great lengths to remove the Omega 3 in
order to increase the shelf life of foods.
Milling and refining grains to produce
white flour eliminates Omega 3. Also, the
refining and hydrogenation processes
effectively remove Omega 3 from
commercially available vegetable oils.
Another problem exists in the way our
animals are currently raised. In "the good
old days", animals wandered around
eating a varied diet. Today, most animals
raised for food are kept in feed lots where
they are fed a processed grain diet from
which most of the Omega 3 has been
removed. Animals are like humans. They
cannot manufacture Omega 3 and Omega
6. As a result, those who consume high
amounts of animal meat are likely to have
an unbalanced ratio of essential fatty
acids, particularly the Omega 3.
In our body Omega 3 and Omega 6 go
through a number of changes and are
converted into other, more familiar
families of fatty acids.
Several steps down the line in the Omega
3 family, fats called eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA)
are produced from Alpha-Linolenic Acid.
On the Omega 6 side, fats like Gamma
Linolenic Acid (GLA) are produced if all
of the components are available, including
arachidonic fatty acids.
We need a balance and
proper ratio of Omega
3 and Omega 6
The most compelling reason we need this
balance is because these essential fatty
acids are precursors for prostaglandin
production in the body.
The prostaglandins are a very important
group of hormonelike chemicals that
regulate virtually every major body
function, including blood pressure, fluid
retention, blood cell stickiness,
inflammation, allergies, fever, and the
immune system, just to name a few!
Over fifty different prostaglandins have
been discovered so far and scientists
speculate that hundreds will eventually
be found.
Sometimes we refer to these
prostaglandins as "good" and "bad "
because they can have both negative and
positive effects. However, this is not
technically correct because we often need
both effects, but at different times.
Blackcurrant Seed Oil
one of the best sources of Omega 3 and Omega 6.
There are several plant oils available that provide some essential fatty
acids: Borage, Primrose, Safflower, and Flax. Some oils, such as Flax
and Safflower, lack GLA. Oils like Borage and Primrose do not contain
Alpha-Linolenic Acid. While all of these oils can be good if taken
in the proper ratio and balance, one oil, Blackcurrant Seed Oil,
appears to provide a balanced profile of Linoleic, Linolenic, Alpha Linolenic
(ALA) and Gamma Linolenic Acid (GLA).

For example, too much platelet stickiness
produces blood clots that can cause
strokes and heart attacks. Consequently,
the prostaglandin that causes platelet
stickiness is often labeled a "bad"
prostaglandin. But what if you cut your
finger? Now you need some platelet
stickiness to form a scab so that you don't
bleed to death. Now we refer to it as a "good" prostaglandin.
We need both reactions. We need
different prostaglandins and, as such, we
need the Essential Fatty Acid balance and
ratio that provides the right response
from the right prostaglandin.
Unfortunately, the Standard American
Diet (SAD) frequently produces too much
prostaglandin (an imbalance) which leads
to platelet stickiness and blood clots.
This is a major problem, as this is a
contributing factor to cardiovascular
disease, heart attacks, strokes and
countless other problems.
For example, too much platelet stickiness
produces blood clots that can cause
strokes and heart attacks. Consequently,
the prostaglandin that causes platelet
stickiness is often labeled a "bad"
prostaglandin. But what if you cut your
finger? Now you need some platelet
stickiness to form a scab so that you don't
bleed to death. Now we refer to it as a
"good" prostaglandin.
We need both reactions. We need
different prostaglandins and, as such, we
need the Essential Fatty Acid balance and
ratio that provides the right response
from the right prostaglandin.
Unfortunately, the Standard American
Diet (SAD) frequently produces too much
prostaglandin (an imbalance) which leads
to platelet stickiness and blood clots.
This is a major problem, as this is a
contributing factor to cardiovascular
disease, heart attacks, strokes and
countless other problems.
Therefore, it is necessary for us to
consume oils that have the proper ratio
of Omega 6 to Omega 3. (See Dr. Karmali's
statement above: "The best ratio is a one
to one ratio.")
Why we need
Gamma Linolenic
Acid (GLA)
As you can see, from Figure 1, not all
sources of Essential Fatty Acids contain
Gamma Linolenic Acid (GLA). In fact, in
nature, there are only a few sources. One
is mother's milk, which scientists have
determined helps the baby develop a
stong immune system. Additional plant
souces include Borage, Evening
Primrose and Blackcurrant Seed Oil.
In essence, GLA is the form Linoleic Acid
takes when it is broken down properly in
the body. However, research shows that
individuals with diabetes and people whocannot form GLA from Linoleic Acid
should be sure that they have an
adequate source of GLA in the diet. GLA
supplementation in diabetes has been
shown to improve nerve functions and
prevent diabetic nerve disease.4
GLA has a remarkable
range of therapeutic
properties, including a
pivotal role in PGI
prostaglandin production.
In 1980, Dr. David F. Horrobin and
scientists at the Efamol Research Institute
in Kentville, Nova Scotia, sugested
that, "Cancer cells cannot make a substance
that converts Linoleic into
Gamma Linolenic Acid." This lack " may
be the critical step in the malignant
change in many forms of cancer." By
providing Gamma Linolenic Acid, Dr.
Horrobin concluded,"physicians could
normalize malignant cells and reverse
cancer's growth."5
In a critical test of Horrobin's theory,
South Africa scientists showed that GLA
Supplements produced a " highly significant
reduction" in the growth rate of human
liver cancer cells in the test tube, up
to 87 percent, and "requires urgent further
investigation at all levels, including
trials in human cancer patients." 6
Doctors at the Children's Research Hospital
of Kyoto Prefectual University of
Medicine, Japan, studied the effects of
GLA on two types of human nerve cancer
cells. Growth was inhibited and this
was associated with "striking membrane
fatty acid changes." Researchers concluded
that the anticancer effect of GLA
is probably due to the " cellular dysfunction"
of tumor cells after GLA was incorporated
into their structures. Kyoto scientists
further concluded that GLA by itself
shows antitumor activities in various
cell cultures.7
While scientists generally try to stop free
radical activity, GLA may work by
causing deadly free radicals to form in
cancerous, but not in normal cells. GLA
was more effective than Linoleic Acid in
this regard.8
Researchers at Rhodes University in
South Africa studied the effects of purified
Linoleic Acid and GLA on melanoma
cells. They also looked at the effect of
Safflower Oil and Evening Primrose Oil |
The Benefits of GLA
The rationale for supplementing the diet with GLA is to support
the weakened or missing step in the production of
PGI prostaglandins.
PGI prostaglandins play a pivotal role in:
• Reducing the tendency of blood to clot
• Widening blood vessels and preventing
vessel spasms
• Reducing the severity and extent of heart damage
during a heart attack
• Preventing and relieving angina pains
• Healing ulcers caused by faulty circulation
• Supporting the immune system
• Reducing or preventing inflammation of arthritis
• Relieving the painful inflammation of arthritis
• Maintaining healthy, positive mood and
mental functioning
• Supporting a healthy brain and nervous system
Therapeutically, GLA supplements,
which boost the body's natural supply of PGI,
have been used to:
• Relieve premenstrual syndrome
• Slightly improve the condition of people with
multiple sclerosis
• Lower high blood pressure
• Reduce the tendency of the blood to clot
• Improve circulation and relieve pain in people with
intermittent claudication
• Restore healthy skin condition in people
with eczema
• Relieve inflammation and pain in arthritis |
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(which contain Linoleic Acid) on melanomas
grown in mice. Both were found to
have equal potency in inhibiting the
growth of such cells.9
A group of Scottish doctors concluded
that a fatty acid deficiency may predispose
people to develop bladder cancer,rather than itself be a result of
the cancer.10
Nutritional intervention to increase the
proportion of Essential Fatty Acids in the
diet may have a role in the management
of breast carcinoma.11 |
Recommendations to achieve a
balanced ratio of EFA, ALA & GLA
1 Select a good source of cholesterol free marine lipids
(derived from deep cold water fish) providing a
minimum of :
540 mg of EPA*
360 mg of DHA
Fish oil is a good source of Omega 3 fatty acids, particularly
EPA (eicosapentaenoic) and DHA (docosahexaenoic).
Biochemically EPA and DHA actually compete with, displace
and inhibit arachidonic acid (a sometimes bad fatty
acid) metabolism.12 Recent evidence suggests that chemicals
derived from Arachidonic Acid can produce a variety
of metabolites that can initiate and promote tumor function
and vascularization, cell proliferation, tissue invasiveness,
metastasis and suppression of the immune
surveillance system.13
2 Consume a high quality plant source of Blackcurrant
Seed Oil providing:
560 mg of pure Blackcurrant Seed Oil**
80 mg of GLA.
For those on a strict vegetarian diet, the consumption of
additional Blackcurrant Seed Oil (a total of at least 1000 mg
of Blackcurrant Seed Oil and at least 120 mg of GLA) or a
variety of plant oils is recommended to achieve an adequate
and balanced profile of EFAs and GLA.
Individuals with diabetes and people who cannot form GLA
from Linoleic Acid should be sure that they have an adequate
source of GLA in their diet. GLA supplements in
diabetics have been shown to improve nerve function and
prevent diabetic nerve disease.14
3 Add healthy Essential Fatty Acids to your diet everyday.
New Spirit has food based products that can easily be
added to your diet to support your need for these important
dietary componsents: Green Magic, Golden Omega-
Omega (includesFlax Oil), and Lecithin.
4 Take a minimum of 400 IUs of Natural Vitamin E daily.
The best supplement is one that contains a mixedsource
of Vitamin E, Wheatgerm Oil & Lecithin. Vitamin E is
essential to help prevent lipid peroxidation.
* Most marine lipids will contain 180 mg of EPA & 120
mg of DHA per capsule. Therefore, it is necessary to
take a minimum of 3 capsules.
** It usually requires two capsules to achieve this level.
The oil should be cold processed, without solvents. |
The ideas, procedures and suggestions in this article
are intended to supplement, not replace, the medical
advice of trained professionals. In addition, all
matters regarding your health require medical
supervision. Consult your physician about any
condition that may require diagnosis or medical
attention.
References
1Wynder, E.L., "Amount and Type of Fat/Fiber in Nutritional
Carcinogenesis", Preventive Medicine 16:451(1987)
2Richard A. Passwater PhD., Cancer Prevention and Nutritional
Therapies. Keats Publishing, 1993. p.139.
3 Pelton, Ross R.P.,Ph, PhD andOverholser, Lee PhD, Alternatives
in Cancer Therapy. Simon & Schuster, New York, 1994. p
89
4Whitaker, Julian, M.D., Dr. Whitaker's Guide to Natural Healing,
Prima Publishing, Rocklin, Ca. 1995. p.505 Moss, Ralph W.
PHD, Cancer Therapy, The Independent Consumer's Guide to
Non-Toxic Treatment and Prevention, Equinox Press, Brooklyn,
New York, 1996. p.217-218.
6 Ibid.
7 Ibid. p.219.
8 Ibid, p.220.
9 Ibid.
10 Ibid.
11Pritchard, GA, et al, Lipids in Brreast Carcinogensis. Br. J.
Surg. 1989;76:1069-77.
12Ross Pelton, R.P.., PH.D. and Lee Overholser, PH.D., Alternatives
in Cancer Therapy, Simon & Schuster, New York, 1994.
p.92.
13 Ibid. p.92
14Horrobin, DF: Fatty acid Metabolism in Health and Disease:
The Role of Delta-6-desaturase. Am J. Clin Nutrition 57:732s,
1993. |
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| Information contained in this bulletin is for informational and educational purposes only and is not intended as a substitute for
advise from your physician. This information should not be used for diagnosis or treatment of any health problem. You should
consult with a health care professional for treatment of any health issue. |
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