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Dehydroepiandosterone, A Dietary Supplement


Suggested Retail Price:$19.95
Your Price:$14.96

The Premise: At age 35, many individuals begin to fatigue more easily, experience a gradual loss of muscle mass and are not as effective at fighting off disease. Some of these changes are likely due to inactivity and life-style. The reality is that even those who watch their diet and exercise daily are effected by the aging process.

Declining DHEA and the corresponding decline in dependent steroid hormones has been linked to the loss of muscle tissue and stamina, fatigue, increased body fat, a decline in sex drive and an increased susceptibility to disease.

Although the specific mechanisms of action for DHEA are only partially understood, supplemental DHEA has been shown to have a positive influence on markers that define aging, obesity and cancer.

What we know about DHEA and its effect on aging:
DHEA (Dehydroepiandrosterone) is a steroid hormone produced in the adrenal gland early in the day. It is the most abundant steroid in the bloodstream and is present at even higher levels in brain tissue.

DHEA levels are known to decline with age. (see chart) It appears in the blood steam by age seven and reaches its peak between 25 and 30. Production declines

gradually, falling as much as 90% by age 60. (Danenberg, 1986)

DHEA is known to be a precursor to the numerous steroid sex hormones, including estrogen and testosterone.

Scientific Studies reinforce the benefits of DHEA

DHEA and Your Immune System
Researchers concluded that administering DHEA to rats restored specific immune function known to put
• the elderly at increased risk of pneumonia, influenza and other diseases. DHEA was shown to improve macrophage function by correcting defective pathways of cell to cell transduction. Macrophage immune deficiencies are known to shorten survival in cancer patients. (Journal of Immunology, 2002)

• DHEA has consistently been shown to boost beneficial interleukin-2 and suppress damaging interkeukin-6 levels. Interleukin-6 is overproduced in the aged, which contributes to autoimmune disease, immune dysfunction, osteoporosis, depressions in healing, breast cancer, B-cell lymphoma, and anemia. (Van Vollenhoven, 1998)

• Oral supplementation with low dose DHEA in aged animals restored immunocompetence to a reasonable level within days of administration. (Danenberg, 1996)

DHEA and Blood Sugar Metabolism/Weight Management
•DHEA (50-100 mg. a day) was shown to significantly elevate insulin growth factor (IGF). Aging causes a decline in IGF level that contributes to the loss of lean body mass, as well as excess fat accumulations, neurological impairment and age-associated immune dysfunction. (Morales, 1998)
Focusing on healthy men, DHEA (50 mg.) was administered orally for a two week period. DHEA levels increased by 3-4 times compared to the placebo. Researchers noted the following:

§ An increase of 20% in IGF-1.

§ An increase of 35% in the number of monocyte immune cells.

§ An increase of 29% in the number of B immune cells and a 62% increase in B cell activity.

§ A 40% increase in T-cell activity, even though the total number of T-cells was not affected.

§ An increase of 50% in interleukin-2.

§ An increase of 22-37% in natural killer cells (NK) and an increase of 45% in (NK) cell activity.

§ No adverse effects were noted with DHEA administration.

DHEA, Your Brain and Sense of Well-being
• DHEA may protect against Alzheimer’s disease by blocking the toxic effect of cortisol and boosting IGF levels. Scientists noted that DHEA’s protective effect could be of benefit to the normal aging brain. (Journal of Endocrinology Investigations, 2002)
• S.S.C. Yen and Associates at the University of California San Diego tested the effects of DHEA Supplementation (50 mg. a day) over a 6 month period. Researchers reported that youthful serum levels of DHEA were restored in both men and women. Dr. Yen showed that DHEA replacement was associated with an increase in perceived physical and psychological well being for both men (67%) and women (84%). (Morales, 1994)

DHEA and Your Bone Health
Doctors noted that DHEA is a factor that determines lumbar spine density in aging men. Previously it was shown that DHEA helps to protect bone mineral density in women. (Calcified Tissue International, 2003)

DHEA and Heart Disease
• Men with high DHEA levels are less likely to die of cardiovascular disease. Moreover, DHEA increases the body’s ability to transform food into energy and burn off excess fat. The study also concluded that DHEA has antiinflammatory properties. Chronic inflammation is known to play a critical role in the development of the killer diseases of aging: heart disease, Alzheimer’s disease and certain types of cancers. The (Journal of the Medical Association of Thailand, 2003)
• A study using coronary artery angiography showed that low DHEA levels predispose people to more significant coronary artery blockage. (Herrington, 1995)
• DHEA inhibits abnormal blood platelet aggregation, a major factor in the development of sudden heart attack and stroke. In contrast, some studies on DHEA do not show cardiovascular disease protection. (Jesse, 1995)

DHEA and Cancer
DHEA may effective in the prevention and treatment of cancer. In one study, DHEA inhibited tumor proliferation of rat liver cells by blocking the cancer promoting enzyme glucose 6-phosphate dehydrogenase (G6PDH). The human equivalent dose of 600 mg. a day suppressed breast tumors in mice by 70%. Scientists showed that even human equivalent doses of 25-120 mg. showed striking cancer prevention benefits with no evidence of toxicity. (Simile, 1995) (Khorram, 1997)
The statements contained in this brochure have not been evaluated by the Food & Drug Administration, nor is this product intended to diagnose, treat, cure or prevent any disease. Information may be useful when working with your health care professional.